Title
Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA.
Abstract
Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2\'-oxygen and the 4\'-carbon. This conformation restriction increases binding affinity for complementarity sequences and provides an exciting new chemical approach for the control of gene expression and optimization of microarrays.
Authors
Braasch DA, Corey DR.
Journal
Chem. Biol., 2001 : 8(1), 1~7
PMID
11182314
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